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Estrogen Receptor (ESR1) Antibody
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Catalogue No: abx000676
Price:
£120.00
(Size: 20 µl)
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ESR1 Antibody is a Rabbit Polyclonal antibody against ESR1. This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.
Research Articles on ESR1
| Target | ESR1 |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000 - 1/4000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human Estrogen Receptor alpha (NP_000116.2). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P03372 (UniProt, ExPASy) |
| UniProt Secondary AC | Q13511, Q14276, Q5T5H7, Q6MZQ9, Q9NU51, Q9UDZ7, Q9UIS7 |
| UniProt Entry Name | ESR1_HUMAN |
| Gene Symbol | ESR1 |
| GeneID | 2099 |
| KEGG | hsa:2099 |
| String | 9606.ENSP00000405330 |
| Molecular Weight | Calculated MW: 35 kDa, 47 kDa, 53 kDa, 66 kDa Observed MW: 75 kDa |
| Buffer | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration | 3.64 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
