Ewing Sarcoma Breakpoint Region 1 (EWSR1) Antibody

EWSR1 Antibody is a Rabbit Polyclonal antibody against EWSR1. This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Target	Ewing Sarcoma Breakpoint Region 1 (EWSR1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human EWSR1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q01844 (UniProt, ExPASy)
UniProt Secondary AC	B0QYK1, Q5THL0, Q92635, Q96FE8, Q96MN4, Q96MX4, Q9BWA2
UniProt Entry Name	EWS_HUMAN
Gene Symbol	EWSR1
GeneID	2130
NCBI Accession	NP_001156757.1
KEGG	hsa:2130
String	9606.ENSP00000400142
Molecular Weight	Calculated MW: 68 kDa Observed MW: 75 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ewing Sarcoma Breakpoint Region 1 (EWSR1)

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