Ewing Sarcoma Breakpoint Region 1 (EWSR1) Antibody

Catalogue No: abx001418
Price: £120.00
(Size: 20 µl)
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EWSR1 Antibody is a Rabbit Polyclonal antibody against EWSR1. This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Target EWSR1
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human EWSR1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q01844 (UniProt, ExPASy)
UniProt Secondary AC B0QYK1, Q5THL0, Q92635, Q96FE8, Q96MN4, Q96MX4, Q9BWA2
UniProt Entry Name EWS_HUMAN
Gene Symbol EWSR1
GeneID 2130
KEGG hsa:2130
String 9606.ENSP00000400142
Molecular Weight Calculated MW: 37 kDa, 61 kDa, 62 kDa, 68 kDa
Observed MW: 105 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on EWSR1

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