Coagulation Factor III, Tissue Factor / CD142 (F3) Antibody

F3 Antibody is a Rabbit Polyclonal antibody against F3. This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

Target	Coagulation Factor III, Tissue Factor / CD142 (F3)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/100 - 1/500, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 120-251 of human Coagulation factor III/Tissue Factor.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P13726 (UniProt, ExPASy)
UniProt Secondary AC	D3DT47, Q6FHG2, Q86WH4
UniProt Entry Name	TF_HUMAN
Gene Symbol	F3
GeneID	2152
NCBI Accession	NP_001984.1
KEGG	hsa:2152
String	9606.ENSP00000334145
Molecular Weight	Calculated MW: 33 kDa Observed MW: 53/45 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Coagulation Factor III, Tissue Factor / CD142 (F3)

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