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Fanconi Anemia Complementation Group D2 (FANCD2) Antibody

Catalogue No: abx001687
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Fanconi Anemia Complementation Group D2 (FANCD2) Antibody Fanconi Anemia Complementation Group D2 (FANCD2) Antibody Fanconi Anemia Complementation Group D2 (FANCD2) Antibody

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FANCD2 Antibody is a Rabbit Polyclonal antibody against FANCD2. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

Target FANCD2
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human FANCD2.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9BXW9 (UniProt, ExPASy)
UniProt Secondary AC Q2LA86, Q69YP9, Q6PJN7, Q9BQ06, Q9H9T9
UniProt Entry Name FACD2_HUMAN
Gene Symbol FANCD2
GeneID 2177
String 9606.ENSP00000287647
Molecular Weight Calculated MW: 27 kDa, 140 kDa, 164 kDa, 166 kDa
Observed MW: 175 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Fanconi Anemia Complementation Group D2 (FANCD2) Antibody

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