TNF Receptor Superfamily Member 6 / CD95 / TNFRSF6 (FAS) Antibody

The protein encoded by this gene is a member of the TNF-receptor superfamily.This receptor contains a death domain.It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system.The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10.The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis.This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells.Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD).The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Target	TNF Receptor Superfamily Member 6 / CD95 / TNFRSF6 (FAS)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human FAS expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P25445 (UniProt, ExPASy)
UniProt Entry Name	TNR6_HUMAN
Gene Symbol	FAS
GeneID	355
OMIM	134637
HGNC	11920
KEGG	hsa:355
Ensembl	ENSG00000026103
String	9606.ENSP00000347979
Molecular Weight	37.7 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on TNF Receptor Superfamily Member 6 / CD95 / TNFRSF6 (FAS)

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