Fc Fragment of IgG Low Affinity IIIa Receptor (FCGR3A) Antibody

FCGR3A Antibody is a Rabbit Polyclonal antibody against FCGR3A. This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	Fc Fragment of IgG Low Affinity IIIa Receptor (FCGR3A)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 150-250 of human FCGR3A.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08637 (UniProt, ExPASy)
UniProt Secondary AC	A2N6W9, Q53FJ0, Q53FL6, Q5EBR4, Q65ZM6, Q6PIJ0
Gene Symbol	FCGR3A
GeneID	2214
NCBI Accession	NP_000560.7
Molecular Weight	Calculated MW: 29 kDa Observed MW: 60 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Fc Fragment of IgG Low Affinity IIIa Receptor (FCGR3A)

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