Farnesyl Diphosphate Synthase (FDPS) Antibody
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Catalogue No: abx031597
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US$326.25
(Size: 80 µl)
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Datasheet SDS
The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes.1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.
Research Articles on Farnesyl Diphosphate Synthase (FDPS)
| Target | Farnesyl Diphosphate Synthase (FDPS) |
| Research Area | Enzymes and Kinases |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 389-419 amino acids from the center region of human FDPS. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P14324 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DV91, E9PCI9, Q96G29 |
| UniProt Entry Name | FPPS_HUMAN |
| NCBI Accession | NP_001129293.1 NP_001129294.1 NP_001229753.1 NP_001229754.1 NP_001995.1 |
| KEGG | hsa:2224 |
| String | 9606.ENSP00000349078 |
| Molecular Weight | Calculated MW: 48.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |