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Flap Structure Specific Endonuclease 1 (FEN1) Antibody

Catalogue No: abx001089
Price: £120.00
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Flap Structure Specific Endonuclease 1 (FEN1) Antibody Flap Structure Specific Endonuclease 1 (FEN1) Antibody Flap Structure Specific Endonuclease 1 (FEN1) Antibody Flap Structure Specific Endonuclease 1 (FEN1) Antibody

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FEN1 Antibody is a Rabbit Polyclonal antibody against FEN1. The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

Target FEN1
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IHC, IF/ICC, IP
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/10 - 1/100, IP: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human FEN1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P39748 (UniProt, ExPASy)
UniProt Entry Name FEN1_HUMAN
Gene Symbol FEN1
GeneID 2237
KEGG hsa:223
String 9606.ENSP00000305480
Molecular Weight Calculated MW: 35 kDa, 42 kDa
Observed MW: Refer to Figures
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Flap Structure Specific Endonuclease 1 (FEN1) Antibody

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