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Fibroblast Growth Factor Receptor 1 (FGFR1) Antibody
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Catalogue No: abx011769
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US$427.75
(Size: 100 µl)
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Datasheet SDS
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome. The genomic organization of this gene is very similar to family members 2-4, encompassing 19 exons that are subject to complex alternative splicing, which allows for structural, tissue expression and ligand affinity variations among the isoforms.
Research Articles on Fibroblast Growth Factor Receptor 1 (FGFR1)
| Target | Fibroblast Growth Factor Receptor 1 (FGFR1) |
| Research Area | Cellular Differentiation and Adhesion, Tumor Immunity, Infection Immunity, Immunology, Autoimmunity, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant extracellular fragment of human FGFR1 (aa22-376) fused with hIgGFc tag expressed in HEK293 cells. |
| Isotype | IgG2b |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P11362 (UniProt, ExPASy) |
| UniProt Entry Name | FGFR1_HUMAN |
| Gene Symbol | FGFR1 |
| GeneID | 2260 |
| OMIM | 136350 |
| HGNC | 3688 |
| KEGG | hsa:2260 |
| Ensembl | ENSG00000077782 |
| String | 9606.ENSP00000393312 |
| Molecular Weight | 92 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |