Fibroblast Growth Factor Receptor 1 (FGFR1) Antibody

FGFR1 Antibody is a Rabbit Polyclonal antibody against FGFR1. The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Target	Fibroblast Growth Factor Receptor 1 (FGFR1)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	ELISA
Host	Rabbit
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 22-290 of human FGFR1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P11362 (UniProt, ExPASy)
UniProt Entry Name	FGFR1_HUMAN
Gene Symbol	FGFR1
GeneID	2260
NCBI Accession	NP_075598.2
KEGG	hsa:2260
String	9606.ENSP00000393312
Molecular Weight	Calculated MW: 92 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Fibroblast Growth Factor Receptor 1 (FGFR1)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue