Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody

FGFR2 Antibody is a Rabbit Polyclonal antibody against FGFR2. The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Target	Fibroblast Growth Factor Receptor 2 (FGFR2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	IHC
Host	Rabbit
Recommended dilutions	IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FGFR2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P21802 (UniProt, ExPASy)
UniProt Entry Name	FGFR2_HUMAN
Gene Symbol	FGFR2
GeneID	2263
NCBI Accession	NP_000132.3
KEGG	hsa:2263
String	9606.ENSP00000410294
Molecular Weight	Calculated MW: 92 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Fibroblast Growth Factor Receptor 2 (FGFR2)

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