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Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody

Catalogue No: abx001689
Price: £120.00
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Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody

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FGFR2 Antibody is a Rabbit Polyclonal antibody against FGFR2. The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Target FGFR2
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human FGFR2.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P21802 (UniProt, ExPASy)
UniProt Entry Name FGFR2_HUMAN
Gene Symbol FGFR2
GeneID 2263
KEGG hsa:2263
String 9606.ENSP00000410294
Molecular Weight Calculated MW: 28 kDa, 40 kDa, 76-92 kDa
Observed MW: 100 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody

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