Fragile Histidine Triad (FHIT) Antibody

FHIT Antibody is a Rabbit Polyclonal antibody against FHIT. This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009].

Target	Fragile Histidine Triad (FHIT)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 25-147 of Human FHIT.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49789 (UniProt, ExPASy)
UniProt Secondary AC	A2IAS9, A2IAT0, A2IAT6, A8K1A9, Q45QG9, Q6IU12
UniProt Entry Name	FHIT_HUMAN
Gene Symbol	FHIT
GeneID	2272
NCBI Accession	NP_001159715.1
KEGG	hsa:2272
String	9606.ENSP00000417480
Molecular Weight	Calculated MW: 17 kDa Observed MW: 17 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	3.09 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Fragile Histidine Triad (FHIT)

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