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Mouse Fibrillin 1 (FBN1) Protein
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Catalogue No: abx692999
Price:
US$377.00
(Size: 10 µg)
Orders to United States ship from United States
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Mouse Fibrillin-1 Protein is a recombinant protein from Mouse produced in HEK293 cells. The target gene encoding Ser2732-His2871 is expressed with an N-terminal His tag. Fibrillin-1 is a protein produced by white adipose tissue in mammals, which stimulates the liver to release glucose into the blood stream, via a cAMP-dependent pathway. This process is vital for brain function and survival during fasting. Neonatal progeroid syndrome results in lack of Fibrillin-1, while insulin resistance causes an abundance of Fibrillin-1. Fibrillin-1 has been proposed as a target for Type 2 Diabetes treatment- when antibodies targeting Fibrillin-1 were injected into diabetic mice, blood glucose and insulin levels improved.
Research Articles on Fibrillin-1
| Target | Fibrillin-1 |
| Origin | Mouse |
| Expression | Recombinant |
| Tested Applications | SDS-PAGE |
| Host | Human |
| Form | Lyophilized |
| Activity | Not tested |
| Purity | > 80% (SDS-PAGE) |
| Purification | 0.2 µm filtered. |
| Storage | Aliquot and store at -20°C for up to 1 year. Avoid repeated freeze/thaw cycles. |
| Stability | Stable when stored reconstituted at 4-8 °C for up to 1 week. Reconstituted aliquots are stable at < -20 °C for up to 3 months. |
| UniProt Primary AC | Q61554 (UniProt, ExPASy) |
| UniProt Secondary AC | A2AQ53, Q60826 |
| UniProt Entry Name | FBN1_MOUSE |
| NCBI Accession | AAA56840.1 |
| KEGG | mmu:14118 |
| String | 10090.ENSMUSP00000028633 |
| Molecular Weight | Calculated MW: 16.9 kDa Observed MW (SDS-PAGE): 30 kDa |
| Sequence Fragment | Ser2732-His2871 |
| Tag | N-terminal His tag |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5-8% Trehalose, Mannitol and 0.01% Tween-80. |
| Endotoxin Level | < 1.0 EU per µg (LAL method). |
| Availability | Shipped within 5-15 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |