Fibulin 5 (FBLN5) Antibody
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Catalogue No: abx010782
Price:
US$427.75
(Size: 100 µl)
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Datasheet SDS
Fibulin 5 (FBLN5), with 448-amino acid protein (about 50kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
Research Articles on Fibulin 5 (FBLN5)
| Target | Fibulin 5 (FBLN5) |
| Research Area | Developmental Science |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of Fibulin 5 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9UBX5 (UniProt, ExPASy) |
| UniProt Secondary AC | O75966, Q6IAL4, Q6UWA3 |
| UniProt Entry Name | FBLN5_HUMAN |
| Gene Symbol | FBLN5 |
| GeneID | 10516 |
| OMIM | 219100 |
| HGNC | 3602 |
| Ensembl | ENSG00000140092 |
| String | 9606.ENSP00000345008 |
| Molecular Weight | 50 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |