FKBP4 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy.
Target |
FK506 Binding Protein 4 (FKBP4) |
Clonality |
Polyclonal |
Reactivity |
Human |
Tested Applications |
ELISA, WB, FCM |
Host |
Rabbit |
Recommended dilutions |
WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
KLH-conjugated synthetic peptide between 186-216 amino acids from the Central region of human FKBP4. |
Isotype |
IgG |
Form |
Liquid |
Purification |
Purified Rabbit Polyclonal Antibody. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
Q02790 (UniProt,
ExPASy)
|
UniProt Secondary AC |
D3DUQ1, Q9UCP1, Q9UCV7 |
UniProt Entry Name |
FKBP4_HUMAN |
KEGG |
hsa:2288
|
String |
9606.ENSP00000001008
|
Molecular Weight |
Calculated MW: 51.8 kDa |
Buffer |
PBS containing 0.09% sodium azide. |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on FK506 Binding Protein 4 (FKBP4)