+44 (0) 1223 755950
+1 832 327 7413
Forkhead Box Protein O3 (FOXO3A) Antibody
REQUEST MORE INFO
Catalogue No: abx011937
Price:
US$406.00
(Size: 100 µg)
Orders to United States ship from United States
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
Forkhead Box Protein O3 (FOXO3A) Antibody is a Rabbit Polyclonal antibody for the detection of FOXO3A. Forkhead box O-class (FOXO) transcription factors are mammalian homologue of DAF-16, a known lifespan regulator of Caenorhabditis elegans. FOXO transcription factors, such as FOXO1, FOXO3a, and FOXO4, have been linked to the regulation of cell cycle, apoptosis, DNA repair, oxidative stress, and metabolism. FOXO proteins are proposed to be dual regulated by Akt-mediated phosphorylation and Skp2-mediated ubiquitination, which are usually initiated by growth factors and cytokines. FOXO proteins are also activated by stress, which induces gene expression that contributes to cell cycle arrest, implicating FOXO proteins as tumor suppressors. Specifically, FOXO3a (FKHR-L1) is a transcriptional activator for apoptosis in the absence of survival factors, such as in neural cell death triggered by oxidative stress. In the presence of survival factors like IGF-1, AKT1/PKB phosphorylates on Thr-32 and Ser-253. FOXO3a is inactivated when phosphorylated by AKT1 on Thr-32 and Ser-253.
Research Articles on Forkhead Box Protein O3 (FOXO3A)
| Target | Forkhead Box Protein O3 (FOXO3A) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | forkhead box O3 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | O43524 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DVZ6, E1P5E6, O15171, Q5T2I7, Q9BZ04 |
| UniProt Entry Name | FOXO3_HUMAN |
| Gene Symbol | FOXO3 |
| GeneID | 2309 |
| OMIM | 602681 |
| HGNC | 3821 |
| KEGG | hsa:2309 |
| Ensembl | ENSG00000118689 |
| String | 9606.ENSP00000385824 |
| Molecular Weight | Observed MW: 90 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |