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Vascular Endothelial Growth Factor Receptor 3 (FLT4) Antibody
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Catalogue No: abx012107
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US$427.75
(Size: 100 µl)
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Datasheet SDS
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. Tissue specificity: Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain. VEGFR-3 is induced in all endothelial cells (EC’s) during early embryogenesis, and its expression eventually disappears from the vascular endothelial cells of adult tissues. VEGFR-3 is constitutively expressed in the adult lymphatic endothelium. Although VEGFR-3 is not expressed in adult blood vessels, it is induced in vascular endothelial cells of tumor-bearing tissues.VEGFR-3 expression in adults is largely restricted to the endothelial cells of the lymphatic system, and high endothelial venules (HEV).
Research Articles on Vascular Endothelial Growth Factor Receptor 3 (FLT4)
| Target | Vascular Endothelial Growth Factor Receptor 3 (FLT4) |
| Research Area | Signal Transduction, Tumor Immunity, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human FLT4 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P35916 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K6L4, B5A926, Q16067, Q86W07, Q86W08 |
| UniProt Entry Name | VGFR3_HUMAN |
| Gene Symbol | FLT4 |
| GeneID | 2324 |
| OMIM | 136352 |
| HGNC | 3767 |
| KEGG | hsa:2324 |
| Ensembl | ENSG00000037280 |
| String | 9606.ENSP00000261937 |
| Molecular Weight | 145 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |