Forkhead Box D3 (FOXD3) Antibody

FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development.This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation.FoxD3 is required for the maintenance of the mammalian neural crest; FoxD3 (-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures.FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells.Promotes development of neural crest cells from neural tube progenitors.Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation.Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.

Target	Forkhead Box D3 (FOXD3)
Clonality	Monoclonal
Reactivity	Human, Mouse, Monkey
Tested Applications	ELISA, WB, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human FOXD3 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
GeneID	27022
Molecular Weight	50 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Forkhead Box D3 (FOXD3)

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