FRAP1 (pT2446) Antibody

FRAP1 belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. FRAP1 is a part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.

Target	FRAP1 (pT2446)
Clonality	Polyclonal
Target Modification	Thr2446
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, DB
Host	Rabbit
Recommended dilutions	DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T2446 of human FRAP1.
Isotype	IgG
Form	Liquid
Purification	Purified by protein A affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with peptides. The antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P42345 (UniProt, ExPASy)
UniProt Secondary AC	Q4LE76, Q5TER1, Q6LE87, Q96QG3, Q9Y4I3
UniProt Entry Name	MTOR_HUMAN
NCBI Accession	NP_004949.1
KEGG	hsa:2475
String	9606.ENSP00000354558
Molecular Weight	Calculated MW: 289 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat MTOR.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on FRAP1 (pT2446)

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