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Frataxin (FXN) Antibody
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Catalogue No: abx001453
Price:
US$217.50
(Size: 20 µl)
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FXN Antibody is a Rabbit Polyclonal antibody against FXN. FXN, also named as FRDA, X25, m81-FXN, d-FXN, m78-FXN and i-FXN, belongs to the frataxin family. It promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. FXN may play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. FXN is cleaved to be 4 chains. The mature form of FXN is 14kd or 18kd.
Research Articles on Frataxin (FXN)
| Target | Frataxin (FXN) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 42-210 of human FXN / Frataxin. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q16595 (UniProt, ExPASy) |
| UniProt Secondary AC | A8MXJ6, C9JJ89, O15545, O95656, Q15294, Q5VZ01 |
| UniProt Entry Name | FRDA_HUMAN |
| Gene Symbol | FXN |
| GeneID | 2395 |
| NCBI Accession | NP_000135.2 |
| KEGG | hsa:2395 |
| String | 9606.ENSP00000366482 |
| Molecular Weight | Calculated MW: 23 kDa Observed MW: 15 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |