Fizzy/cell Division Cycle 20 Related 1 (Drosophila) (FZR1) Antibody

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Target	Fizzy/cell Division Cycle 20 Related 1 (Drosophila) (FZR1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 53-81 amino acids from the N-terminal region of human FZR1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UM11 (UniProt, ExPASy)
UniProt Entry Name	FZR1_HUMAN
Gene Symbol	FZR1
String	9606.ENSP00000378529
Molecular Weight	Calculated MW: 55.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse FZR1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Fizzy/cell Division Cycle 20 Related 1 (Drosophila) (FZR1)

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