Gamma-Aminobutyric Acid Receptor Subunit Alpha-4 (gABRA4) Antibody

gABRA4 Antibody is a Rabbit Polyclonal antibody against gABRA4. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.

Target	Gamma-Aminobutyric Acid Receptor Subunit Alpha-4 (gABRA4)
Clonality	Polyclonal
Reactivity	Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 36-258 of human GABRA4.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P48169 (UniProt, ExPASy)
UniProt Secondary AC	Q8IYR7
UniProt Entry Name	GBRA4_HUMAN
Gene Symbol	GABRA4
GeneID	2557
NCBI Accession	NP_000800.2
KEGG	hsa:2557
String	9606.ENSP00000264318
Molecular Weight	Calculated MW: 62 kDa Observed MW: 72 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Gamma-Aminobutyric Acid Receptor Subunit Alpha-4 (gABRA4)

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