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Glutamate Decarboxylase 1 (GAD1) Antibody

Catalogue No: abx002144
Price: £120.00
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Glutamate Decarboxylase 1 (GAD1) Antibody

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Glutamate Decarboxylase 1 (GAD1) Antibody is a Rabbit Polyclonal antibody against Glutamate Decarboxylase 1 (GAD1). This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Target Glutamate Decarboxylase 1 (GAD1)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human GAD1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q99259 (UniProt, ExPASy) P48318 (UniProt, ExPASy) P18088 (UniProt, ExPASy)
UniProt Secondary AC Q49AK1, Q53TQ7, Q9BU91, Q9UHH4, O08685
UniProt Entry Name DCE1_HUMAN, DCE1_MOUSE, DCE1_RAT
Gene Symbol GAD1
GeneID 2571 14415
OMIM 603513
NCBI Accession NP_000808.2
HGNC 4092
Ensembl ENSG00000128683, ENSMUSG00000070880, 10116.ENSRNOP00000000008
String 10090.ENSMUSP00000092539
Molecular Weight Calculated MW: 25 kDa, 47 kDa, 66 kDa
Observed MW: 67 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Glutamate Decarboxylase 1 (GAD1) Antibody

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