Glutamate Decarboxylase 1 (GAD1) Antibody
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Catalogue No: abx002144
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US$217.50
(Size: 20 µl)
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Datasheet SDS
Glutamate Decarboxylase 1 (GAD1) Antibody is a Rabbit Polyclonal antibody against Glutamate Decarboxylase 1 (GAD1). This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
Research Articles on Glutamate Decarboxylase 1 (GAD1)
| Target | Glutamate Decarboxylase 1 (GAD1) |
| Research Area | Enzymes and Kinases |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GAD67/GAD67/GAD1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q99259 (UniProt, ExPASy) P48318 (UniProt, ExPASy) P18088 (UniProt, ExPASy) |
| UniProt Secondary AC | Q49AK1, Q53TQ7, Q9BU91, Q9UHH4, O08685 |
| UniProt Entry Name | DCE1_HUMAN, DCE1_MOUSE, DCE1_RAT |
| Gene Symbol | GAD1 |
| GeneID | 2571 14415 |
| OMIM | 603513 |
| NCBI Accession | NP_000808.2 |
| HGNC | 4092 |
| Ensembl | ENSG00000128683, ENSMUSG00000070880, 10116.ENSRNOP00000000008 |
| String | 10090.ENSMUSP00000092539 |
| Molecular Weight | Calculated MW: 67 kDa Observed MW: 67 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |