Glutamate Decarboxylase 2 (GAD2) Antibody

Glutamate Decarboxylase 2 (GAD2) Antibody is a Rabbit Polyclonal against Glutamate Decarboxylase 2 (GAD2). This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Target	Glutamate Decarboxylase 2 (GAD2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fragment corresponding to 42-582 AA of human GAD2.
Isotype	IgG
Form	Lyophilized
Purification	Purified by antigen affinity column chromatography.
Reconstitution	Reconstitute in 100 µl of sterile distilled H2O with 50% glycerol.
Storage	Store at -20 °C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q05329 (UniProt, ExPASy)
UniProt Secondary AC	Q9UD87
UniProt Entry Name	DCE2_HUMAN
Gene Symbol	GAD2
GeneID	2572
OMIM	138275
NCBI Accession	NM_000818.2 NM_001134366.1
HGNC	4093
KEGG	hsa:2572
Ensembl	ENSG00000136750
String	9606.ENSP00000365437
Molecular Weight	Observed MW: 65 kDa
Buffer	Prior to lyophilization: 1% BSA and 0.02% NaN3.
Specificity	Predicted to react with Mouse and Rat GAD2.
Concentration	Lyophilized form: Not applicable. After reconstitution: 1 mg/ml.
Availability	Shipped within 7-15 working days.
Note	This product is for research use only.

Research Articles on Glutamate Decarboxylase 2 (GAD2)

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