Glutamate Decarboxylase 2 (GAD2) Antibody
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Catalogue No: abx025417
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US$623.50
(Size: 100 µl)
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Datasheet SDS
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. This antibody is supplied as crude ascites.
Research Articles on Glutamate Decarboxylase 2 (GAD2)
| Target | Glutamate Decarboxylase 2 (GAD2) |
| Research Area | Enzymes and Kinases, Endocrinology, Neuroscience, Autoimmunity |
| Clonality | Monoclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | WB: 1/100 - 1/1600. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 109-138 amino acids from human GAD2. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified crude ascites. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q05329 (UniProt, ExPASy) Q05683 (UniProt, ExPASy) |
| UniProt Secondary AC | Q9UD87 |
| UniProt Entry Name | DCE2_HUMAN, DCE2_RAT |
| Gene Symbol | GAD2 |
| GeneID | 2572 24380 |
| OMIM | 138275 |
| HGNC | 4093 |
| Ensembl | ENSG00000136750, ENSRNOG00000018200 |
| String | 9606.ENSP00000365437 10116.ENSRNOP00000024901 |
| Molecular Weight | Calculated MW: 65.4 kDa |
| Buffer | Ascites containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Pig GAD2. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |