Glutamate Decarboxylase 2 (GAD2) Antibody

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. This antibody is supplied as crude ascites.

Target	Glutamate Decarboxylase 2 (GAD2)
Clonality	Monoclonal
Reactivity	Human, Rat
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/100 - 1/1600. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 109-138 amino acids from human GAD2.
Isotype	IgG1
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q05329 (UniProt, ExPASy) Q05683 (UniProt, ExPASy)
UniProt Secondary AC	Q9UD87
UniProt Entry Name	DCE2_HUMAN, DCE2_RAT
Gene Symbol	GAD2
GeneID	2572 24380
OMIM	138275
HGNC	4093
Ensembl	ENSG00000136750, ENSRNOG00000018200
String	9606.ENSP00000365437 10116.ENSRNOP00000024901
Molecular Weight	Calculated MW: 65.4 kDa
Buffer	Ascites containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Pig GAD2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Glutamate Decarboxylase 2 (GAD2)

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