Glutamate Decarboxylase 2 (GAD2) Antibody

Glutamate Decarboxylase 2 (GAD2) Antibody is a Rabbit Polyclonal against Glutamate Decarboxylase 2 (GAD2). This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Target	Glutamate Decarboxylase 2 (GAD2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q05329 (UniProt, ExPASy) P48320 (UniProt, ExPASy) Q05683 (UniProt, ExPASy)
UniProt Secondary AC	Q9UD87, O35519
UniProt Entry Name	DCE2_HUMAN, DCE2_MOUSE, DCE2_RAT
Gene Symbol	GAD2
GeneID	2572 14417 24380
OMIM	138275
HGNC	4093
Ensembl	ENSG00000136750, ENSMUSG00000026787, ENSRNOG00000018200
String	9606.ENSP00000365437 10090.ENSMUSP00000028123 10116.ENSRNOP00000024901
Molecular Weight	Observed MW: 70 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Glutamate Decarboxylase 2 (GAD2)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue