Glutamate Decarboxylase 2 (GAD2) Antibody

Catalogue No: abx000924
Price: £120.00
(Size: 20 µl)
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Glutamate Decarboxylase 2 (GAD2) Antibody is a Rabbit Polyclonal antibody against Glutamate Decarboxylase 2 (GAD2). This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Target Glutamate Decarboxylase 2 (GAD2)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human GAD2.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q05329 (UniProt, ExPASy) P48320 (UniProt, ExPASy) Q05683 (UniProt, ExPASy)
UniProt Secondary AC Q9UD87, O35519
Gene Symbol GAD2
GeneID 2572 14417 24380
OMIM 138275
HGNC 4093
Ensembl ENSG00000136750, ENSMUSG00000026787, ENSRNOG00000018200
String 9606.ENSP00000365437 10090.ENSMUSP00000028123 10116.ENSRNOP00000024901
Molecular Weight Calculated MW: 65 kDa
Observed MW: 70 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Glutamate Decarboxylase 2 (GAD2)

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