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Glutamate Decarboxylase 2 (GAD2) Antibody
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Catalogue No: abx000924
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US$217.50
(Size: 20 µl)
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Datasheet SDS
Glutamate Decarboxylase 2 (GAD2) Antibody is a Rabbit Polyclonal antibody against Glutamate Decarboxylase 2 (GAD2). This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
Research Articles on Glutamate Decarboxylase 2 (GAD2)
| Target | Glutamate Decarboxylase 2 (GAD2) |
| Research Area | Enzymes and Kinases, Endocrinology, Neuroscience, Autoimmunity |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to GAD2. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q05329 (UniProt, ExPASy) P48320 (UniProt, ExPASy) Q05683 (UniProt, ExPASy) |
| UniProt Secondary AC | Q9UD87, O35519 |
| UniProt Entry Name | DCE2_HUMAN, DCE2_MOUSE, DCE2_RAT |
| Gene Symbol | GAD2 |
| GeneID | 2572 14417 24380 |
| OMIM | 138275 |
| NCBI Accession | NP_001127838.1 |
| HGNC | 4093 |
| Ensembl | ENSG00000136750, ENSMUSG00000026787, ENSRNOG00000018200 |
| String | 9606.ENSP00000365437 10090.ENSMUSP00000028123 10116.ENSRNOP00000024901 |
| Molecular Weight | Calculated MW: 65 kDa Observed MW: 60 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |