Glutamate Decarboxylase 2 (GAD2) Antibody
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Catalogue No: abx103249
US$319.00
US$271.15
(Size: 100 µl)
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Datasheet SDS
Polyclonal Antibody to Glutamate Decarboxylase 2 (GAD2). This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
Research Articles on Glutamate Decarboxylase 2 (GAD2)
| Target | Glutamate Decarboxylase 2 (GAD2) |
| Research Area | Enzymes and Kinases, Endocrinology, Neuroscience, Autoimmunity |
| Clonality | Polyclonal |
| Reactivity | Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | GAD2 (Met1-Ala150) |
| Form | Liquid |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 24 months. |
| UniProt Primary AC | Q05683 (UniProt, ExPASy) |
| UniProt Entry Name | DCE2_RAT |
| Gene Symbol | GAD2 |
| GeneID | 24380 |
| KEGG | rno:24380 |
| Ensembl | ENSRNOG00000018200 |
| String | 10116.ENSRNOP00000024901 |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |