Glutamate Decarboxylase 2 (GAD2) Antibody

Monoclonal Antibody to Glutamate Decarboxylase 2 (GAD2). This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Target	Glutamate Decarboxylase 2 (GAD2)
Clonality	Monoclonal
Reactivity	Rat
Tested Applications	WB, IHC, IF/ICC
Host	Mouse
Recommended dilutions	WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Met1-Ala150
Isotype	IgG2a Kappa
Form	Liquid
Purification	Purified by Protein A and Protein G affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q05683 (UniProt, ExPASy)
UniProt Entry Name	DCE2_RAT
Gene Symbol	GAD2
GeneID	24380
KEGG	rno:24380
Ensembl	ENSRNOG00000018200
String	10116.ENSRNOP00000024901
Buffer	0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability	Shipped within 5-7 working days.
Note	This product is for research use only.

Research Articles on Glutamate Decarboxylase 2 (GAD2)

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