+44 (0) 1223 755950
+1 832 327 7413
Human Glutamate Decarboxylase 2 (GAD2) Protein
REQUEST MORE INFO
Catalogue No: abx060280
Price:
US$551.00
(Size: 100 µg)
Orders to United States ship from United States
(
Click on the image to see the image legend
Add to Cart
Buy It Now
GET A QUOTE
Documents
Datasheet SDS
Human Glutamate Decarboxylase 2 (GAD2) Protein is a recombinant Human protein expressed in E. coli. Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO2. In mammals, GAD exists in two isoforms encoded by two different genes - GAD1 and GAD2. These isoforms are GAD67 and GAD65 with molecular weights of 67 kDa and 65 kDa respectively. GAD65 and GAD67 synthesize GABA at different locations in the cell, at different developmental times, and for functionally different purposes. GAD67 is spread evenly throughout the cell while GAD65 is localized to nerve terminals. GAD67 in DRD1a-expressing neurons plays a key role in the development of LID and they support the hypothesis that altered GABAergic neurotransmission in the direct pathway is involved in dyskinesia.
Research Articles on Glutamate Decarboxylase 2 (GAD2)
| Target | Glutamate Decarboxylase 2 (GAD2) |
| Research Area | Enzymes and Kinases, Endocrinology, Neuroscience, Autoimmunity |
| Origin | Human |
| Expression | Recombinant |
| Tested Applications | ELISA |
| Host | E. coli |
| Form | Liquid |
| Activity | Not tested |
| Purity | > 85% (SDS-PAGE) |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q05329 (UniProt, ExPASy) |
| UniProt Secondary AC | Q9UD87 |
| UniProt Entry Name | DCE2_HUMAN |
| Gene Symbol | GAD2 |
| GeneID | 2572 |
| OMIM | 138275 |
| KEGG | hsa:2572 |
| String | 9606.ENSP00000365437 |
| Molecular Weight | 80 kDa |
| Tag | N-terminal His tag |
| Buffer | Tris-HCl, pH 7.4 ± 0.2, containing 0.02% NaN3. |
| Concentration | 3.9 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |