Lysosomal Acid Glucosylceramidase (GBA1) Antibody
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Catalogue No: abx025534
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US$623.50
(Size: 100 µl)
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Datasheet SDS
This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. This antibody is supplied as crude ascites.
Research Articles on Lysosomal Acid Glucosylceramidase (GBA1)
| Target | Lysosomal Acid Glucosylceramidase (GBA1) |
| Research Area | Enzymes and Kinases |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | WB: 1/100 - 1/1600. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 337-365 amino acids from the Central region of human GC. |
| Isotype | IgM |
| Form | Liquid |
| Purification | Unpurified crude ascites. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P04062 (UniProt, ExPASy) |
| UniProt Entry Name | GLCM_HUMAN |
| Gene Symbol | GBA1 |
| GeneID | 2629 |
| OMIM | 606463 |
| HGNC | 4177 |
| KEGG | hsa:2629 |
| String | 9606.ENSP00000314508 |
| Molecular Weight | Calculated MW: 59.7 kDa |
| Buffer | Ascites containing 0.09% sodium azide. |
| Specificity | Predicted to react with Cow and Pig GBA. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |