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Hexokinase-4 (GCK) Antibody
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Catalogue No: abx004809
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US$348.00
(Size: 60 µl)
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Datasheet SDS
GCK Antibody is a Rabbit Polyclonal antibody against GCK. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Research Articles on Hexokinase-4 (GCK)
| Target | Hexokinase-4 (GCK) |
| Research Area | Enzymes and Kinases, Metabolism, Endocrinology, Nutrition |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human Glucokinase |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P35557 (UniProt, ExPASy) |
| UniProt Secondary AC | A4D2J2, A4D2J3, Q05810 |
| UniProt Entry Name | HXK4_HUMAN |
| Gene Symbol | GCK |
| GeneID | 2645 |
| NCBI Accession | NP_000153.1 |
| KEGG | hsa:2645 |
| String | 9606.ENSP00000223366 |
| Molecular Weight | Calculated MW: 52 kDa Observed MW: 52 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-7 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
