GDNF Family Receptor Alpha 2 (GFRA2) Antibody

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI) linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

Target	GDNF Family Receptor Alpha 2 (GFRA2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 361-390 amino acids from the C-terminal region of human GFRA2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O00451 (UniProt, ExPASy)
UniProt Secondary AC	E9PD47, O15316, O15328, Q58J92, Q6GTR9, Q7Z5C2
UniProt Entry Name	GFRA2_HUMAN
Gene Symbol	GFRA2
KEGG	hsa:2675
String	9606.ENSP00000428518
Molecular Weight	Calculated MW: 51.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse GFRA2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on GDNF Family Receptor Alpha 2 (GFRA2)

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