Galactosidase Alpha (GLA) Antibody

GLA Antibody is a Rabbit Polyclonal antibody against GLA. This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

Target	Galactosidase Alpha (GLA)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 150-429 of human Galactosidase alpha (GLA).
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P06280 (UniProt, ExPASy)
UniProt Secondary AC	Q6LER7
UniProt Entry Name	AGAL_HUMAN
Gene Symbol	GLA
GeneID	2717
NCBI Accession	NP_000160.1
KEGG	hsa:2717
String	9606.ENSP00000218516
Molecular Weight	Calculated MW: 49 kDa Observed MW: 49 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Galactosidase Alpha (GLA)

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