Glutamate Decarboxylase 1 (GAD1) Antibody

Glutamate Decarboxylase 1 (GAD1) Antibody is a Rabbit Polyclonal antibody for the detection of GAD1.

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Target	Glutamate Decarboxylase 1 (GAD1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	glutamate decarboxylase 1
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q99259 (UniProt, ExPASy)
UniProt Secondary AC	Q49AK1, Q53TQ7, Q9BU91, Q9UHH4
UniProt Entry Name	DCE1_HUMAN
Gene Symbol	GAD1
GeneID	2571
OMIM	603513
NCBI Accession	NP_000808.2
HGNC	4092
Ensembl	ENSG00000128683
Molecular Weight	Observed MW: 67 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Glutamate Decarboxylase 1 (GAD1)

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