G Protein Alpha 11 (GNA11) Antibody

GNA11 Antibody is a Rabbit Polyclonal antibody against GNA11. The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations.

Target	G Protein Alpha 11 (GNA11)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human GNA11.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P29992 (UniProt, ExPASy)
UniProt Secondary AC	O15109, Q14350, Q6IB00
UniProt Entry Name	GNA11_HUMAN
Gene Symbol	GNA11
GeneID	2767
NCBI Accession	NP_002058.2
KEGG	hsa:2767
String	9606.ENSP00000078429
Molecular Weight	Calculated MW: 42 kDa Observed MW: 42 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on G Protein Alpha 11 (GNA11)

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