Growth Factor Receptor Bound Protein 10 (GRB10) Antibody

GRB10 Antibody is a Rabbit Polyclonal antibody against GRB10. Growth factor receptor-bound protein 10 (GRB10) is an adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. GRB10 has three consensus domains including pleckstrin homology (PH) domain, SH2/SH3 domain and Ras-associating domain. By binding to kinases, GRB10 suppresses signals from activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. It may play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation.

Target	Growth Factor Receptor Bound Protein 10 (GRB10)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GRB10.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13322 (UniProt, ExPASy)
UniProt Entry Name	GRB10_HUMAN
Gene Symbol	GRB10
GeneID	2887
NCBI Accession	NP_005302.3
KEGG	hsa:2887
String	9606.ENSP00000381793
Molecular Weight	Calculated MW: 67 kDa Observed MW: 70 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Growth Factor Receptor Bound Protein 10 (GRB10)

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