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Growth Factor Receptor Bound Protein 10 (GRB10) Antibody

Catalogue No: abx000789
Price: £120.00
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GRB10 Antibody is a Rabbit Polyclonal antibody against GRB10. Growth factor receptor-bound protein 10 (GRB10) is an adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. GRB10 has three consensus domains including pleckstrin homology (PH) domain, SH2/SH3 domain and Ras-associating domain. By binding to kinases, GRB10 suppresses signals from activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. It may play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation.

Target Growth Factor Receptor Bound Protein 10
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human GRB10.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q13322 (UniProt, ExPASy)
UniProt Entry Name GRB10_HUMAN
Gene Symbol GRB10
GeneID 2887
KEGG hsa:288
String 9606.ENSP00000381793
Molecular Weight Calculated MW: 60 kDa, 62 kDa, 66 kDa, 67 kDa
Observed MW: 70 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Growth Factor Receptor Bound Protein 10 (GRB10) Antibody

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