Glutamate Receptor, Ionotropic, AMPA 1 (GRIA4) Antibody

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq].

Target	Glutamate Receptor, Ionotropic, AMPA 1 (GRIA4)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 296-325 amino acids from the Central region of human GRIA4.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P48058 (UniProt, ExPASy)
UniProt Secondary AC	Q86XE8
UniProt Entry Name	GRIA4_HUMAN
KEGG	hsa:2893
String	9606.ENSP00000282499
Molecular Weight	Calculated MW: 101 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat and Monkey GRIA4.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Glutamate Receptor, Ionotropic, AMPA 1 (GRIA4)

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