Beta-Adrenergic Receptor Kinase 1 (GRK2) Antibody

The product of this gene phosphorylates the beta 2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. (provided by RefSeq)Tissue specificity: Expressed in peripheral blood leukocytes.

Target	Beta-Adrenergic Receptor Kinase 1 (GRK2)
Clonality	Monoclonal
Reactivity	Human, Mouse, Rat, Monkey
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human GRK2 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P25098 (UniProt, ExPASy)
UniProt Secondary AC	B0ZBE1, Q13837, Q6GTT3
UniProt Entry Name	ARBK1_HUMAN
GeneID	156
KEGG	hsa:156
String	9606.ENSP00000312262
Molecular Weight	80 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Beta-Adrenergic Receptor Kinase 1 (GRK2)

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