Glutamate Metabotropic Receptor 1 (GRM1) Antibody

GRM1 Antibody is a Rabbit Polyclonal antibody against GRM1. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Target	Glutamate Metabotropic Receptor 1 (GRM1)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GRM1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13255 (UniProt, ExPASy)
UniProt Entry Name	GRM1_HUMAN
Gene Symbol	GRM1
GeneID	2911
KEGG	hsa:2911
String	9606.ENSP00000354896
Molecular Weight	Calculated MW: 132 kDa Observed MW: 132 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Glutamate Metabotropic Receptor 1 (GRM1)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue