Glutamate Metabotropic Receptor 7 (GRM7) Antibody

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.

Target	Glutamate Metabotropic Receptor 7 (GRM7)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 240-269 amino acids from the N-terminal region of human GRM7.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14831 (UniProt, ExPASy)
UniProt Secondary AC	Q8NFS2, Q8NFS3, Q8NFS4
UniProt Entry Name	GRM7_HUMAN
KEGG	hsa:2917
String	9606.ENSP00000350348
Molecular Weight	Calculated MW: 102 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat GRM7.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Glutamate Metabotropic Receptor 7 (GRM7)

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