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Metabotropic Glutamate Receptor 8 (GRM8) Antibody

Catalogue No: abx002157
Price: £120.00
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Metabotropic Glutamate Receptor 8 (GRM8) Antibody

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GRM8 Antibody is a Rabbit Polyclonal antibody against GRM8. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Target GRM8
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human GRM8.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O00222 (UniProt, ExPASy)
UniProt Entry Name GRM8_HUMAN
Gene Symbol GRM8
GeneID 2918
KEGG hsa:2918
String 9606.ENSP00000344173
Molecular Weight Calculated MW: 55 kDa, 101 kDa
Observed MW: 120 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Metabotropic Glutamate Receptor 8 (GRM8) Antibody

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