Gastrin Releasing Peptide Receptor (GRPR) Antibody

GRPR Antibody is a Rabbit Polyclonal antibody against GRPR. Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

Target	Gastrin Releasing Peptide Receptor (GRPR)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P30550 (UniProt, ExPASy)
UniProt Secondary AC	B2R910
UniProt Entry Name	GRPR_HUMAN
Gene Symbol	GRPR
GeneID	2925
NCBI Accession	NP_005305.1
KEGG	hsa:2925
String	9606.ENSP00000369643
Molecular Weight	Calculated MW: 43 kDa Observed MW: 43 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Gastrin Releasing Peptide Receptor (GRPR)

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