Glycogen Synthase Kinase-3 Beta (GSK3B) Antibody

GSK3B, a member of the Ser/Thr protein kinase family, participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. GSK3B phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. The protein is inhibited when phosphorylated by AKT1 or ILK1. Expressed is detected in testis, thymus, prostate and ovary, and weakly in lung, brain and kidney.

Target	Glycogen Synthase Kinase-3 Beta (GSK3B)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 4-34 amino acids from the N-terminal region of Human GSK3 beta (GSK3B).
Isotype	IgG
Form	Liquid
Purification	Purified by Protein A affinity chromatography, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49841 (UniProt, ExPASy)
UniProt Secondary AC	D3DN89, Q9BWH3, Q9UL47
UniProt Entry Name	GSK3B_HUMAN
HGNC	4617
KEGG	hsa:2932
String	9606.ENSP00000324806
Molecular Weight	Calculated MW: 46.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat GSK3B.
Concentration	2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Glycogen Synthase Kinase-3 Beta (GSK3B)

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