Glutathione S-Transferase P (GSTP1) Antibody

GSTP1 (glutathione-S-transferase, pi 1), also called GST3/DFN7, is a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione.GSTP1 act like a tumor suppressor gene, which when inactivated leads to tumor growth, and the -class glutathione S-transferase is commonly inactivated by somatic CpGisland hypermethylation in cancers of the prostate, liver, and breast.Methylation of regulatory sequences at the GSTP1 gene locus is found in the vast majority (>90%) of prostate carcinomas and is associated with transcriptional down-regulation.

Target	Glutathione S-Transferase P (GSTP1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human GSTP1 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P09211 (UniProt, ExPASy)
UniProt Secondary AC	O00460, Q15690, Q5TZY3
UniProt Entry Name	GSTP1_HUMAN
Gene Symbol	GSTP1
GeneID	2950
OMIM	134660
HGNC	4638
KEGG	hsa:2950
Ensembl	ENSG00000084207
String	9606.ENSP00000381607
Molecular Weight	23 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Glutathione S-Transferase P (GSTP1)

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