G/T Mismatch-Binding Protein (MSH6) Antibody
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Catalogue No: abx147106
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US$420.50
(Size: 100 µg)
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Datasheet SDS
G/T Mismatch-Binding Protein (MSH6) Antibody is a Rabbit Polyclonal antibody for the detection of MSH6. This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
Research Articles on G/T Mismatch-Binding Protein (MSH6)
| Target | G/T Mismatch-Binding Protein (MSH6) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | mutS homolog 6 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P52701 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DF41, B4E3I4, F5H2F9, O43706, O43917, Q8TCX4, Q9BTB5 |
| UniProt Entry Name | MSH6_HUMAN |
| Gene Symbol | MSH6 |
| GeneID | 2956 |
| OMIM | 114500 |
| HGNC | 7329 |
| KEGG | hsa:2956 |
| Ensembl | ENSG00000116062 |
| String | 9606.ENSP00000234420 |
| Molecular Weight | Observed MW: 120 kDa, 160 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |