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Guanine Nucleotide-Binding Protein Subunit Alpha-13 (GNA13) Antibody
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Catalogue No: abx215490
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US$420.50
(Size: 100 µg)
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Datasheet SDS
Guanine Nucleotide-Binding Protein Subunit Alpha-13 (GNA13) Antibody is a Rabbit Polyclonal antibody for the detection of GNA13. Guanine nucleotide-binding proteins (G proteins are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG. GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1 (By similarity. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation.
Research Articles on Guanine Nucleotide-Binding Protein Subunit Alpha-13 (GNA13)
| Target | Guanine Nucleotide-Binding Protein Subunit Alpha-13 (GNA13) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | guanine nucleotide binding protein (G protein), alpha 13 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q14344 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R977, B7Z7R0, F5H1G8, Q8TD70 |
| UniProt Entry Name | GNA13_HUMAN |
| Gene Symbol | GNA13 |
| GeneID | 10672 |
| OMIM | 604406 |
| HGNC | 4381 |
| KEGG | hsa:10672 |
| Ensembl | ENSG00000120063 |
| String | 9606.ENSP00000400717 |
| Molecular Weight | Observed MW: 44 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |