Histone Deacetylase 1 (HDAC1) Antibody

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Catalogue No: abx034835
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.

Target Histone Deacetylase 1 (HDAC1)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA, WB
Host Mouse
Recommended dilutions WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified His-tagged HDAC1 protein
Isotype IgM Kappa
Form Liquid
Purification Purified Mouse Monoclonal Antibody.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q13547 (UniProt, ExPASy)
UniProt Secondary AC Q92534
UniProt Entry Name HDAC1_HUMAN
NCBI Accession NP_004955.2
KEGG hsa:3065
String 9606.ENSP00000362649
Molecular Weight Calculated MW: 55.1 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Histone Deacetylase 1 (HDAC1)


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