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HDAC4 Antibody is a Rabbit Polyclonal antibody against HDAC4. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
| Target |
HDAC4 |
| Clonality |
Polyclonal |
| Reactivity |
Human, Mouse, Rat |
| Tested Applications |
WB, IF/ICC |
| Host |
Rabbit |
| Recommended dilutions |
WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation |
Unconjugated |
| Immunogen |
A synthetic peptide of human HDAC4. |
| Isotype |
IgG |
| Form |
Liquid |
| Purification |
Affinity purified. |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC |
P56524 (UniProt,
ExPASy)
|
| UniProt Secondary AC |
E9PGB9, F5GX36, Q86YH7, Q9UND6 |
| UniProt Entry Name |
HDAC4_HUMAN |
| Gene Symbol |
HDAC4 |
| GeneID |
9759
|
| KEGG |
hsa:975
|
| String |
9606.ENSP00000264606
|
| Molecular Weight |
Calculated MW: 106 kDa, 119 kDa
Observed MW: 117 kDa |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration |
> 1 mg/ml |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
Research Articles on Histone Deacetylase 4 (HDAC4) Antibody
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