HDAC4 / 5 / 9 (pS246 / 259 / 220) Antibody

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Catalogue No: abx000331
Price: US$246.50
(Size: 20 µl)

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Datasheet SDS
HDAC4/5/9 (pS246/259/220) Antibody is a Rabbit Polyclonal antibody against HDAC4/5/9 (pS246/259/220). Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general,they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.

Target HDAC4/5/9 (pS246/259/220)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A phospho specific peptide corresponding to residues surrounding S246 of human HDAC4
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P56524 (UniProt, ExPASy) Q9UQL6 (UniProt, ExPASy) Q9UKV0 (UniProt, ExPASy)
Gene Symbol HDAC4, HDAC5, HDAC9
GeneID 9759/10014/9734
Molecular Weight Calculated MW: 57-65 kDa/97-122 kDa
Observed MW: 125/140 kDa
Buffer PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on HDAC4/5/9 (pS246/259/220)


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